Vincent Nagy1, Ivica Lazúrová2, Ingrid Dravecká2, Jagienka Jautová3, Janette Baloghová3, Ladislav Valanský1, Ľubomír Lachváč1
Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women in reproductive age. Given the complexity of related symptoms of women with PCOS and signs of autosomal inheritance it is presumed to have been the male equivalent of PCOS. Objective of the study: The aim was to determine the existence of a male equivalent of polycystic ovary syndrome (PCOS) in younger men with hormonal imbalance and androgenic alopecia. Clinical material and methods: In 2010-2011 there 22 patients with a mean age of 31.7 ± 7.9 years were examined. Dermatological examination to exclude other causes of alopecia (16/22 in the skin biopsy), urological (sexological) and internal examination were provided. There were examined plasma glucose and insulin levels, with the calculation of insulin resistance index HOMA (Homeostasis Model Assessment: glucose x insulin /22.5), lipids: total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides. In all patients basic hormonal spectrum and anthropometric parameters were examined: total and free testosterone, free androgen index (FAI), sexual hormone binding globulin (SHBG), follicle stimulating hormone (FSH), luteinizing hormone (LH) and anthropometric parameters: weight, height, waist circumference and body mass index (BMI: weight/height2). Results: New onset type 2 diabetes was confirmed in one patient (4.5 %) and insulin resistance was confirmed in three patients (13.6 %). Metabolic dyslipidaemia (hypertriglyceridemia, low HDL cholesterol or elevated LDL cholesterol) occurred in 8 patients (36 %). Increased levels of testosterone were found in only one patient (4.5 %), increased FAI in four patients (18.18 %), and decreased SHBG in two subjects (9 %). Overweight and obesity have been confirmed in 40 % (9 patients). Conclusion: The existence of male equivalent of PCOS has not yet been proven, but there were confirmed features of the metabolic syndrome, marginally higher fasting blood glucose, elevated LDL cholesterol and overweight. There were found significant changes in hormonal parameters.