Zuzana Lysá, Oľga Červeňová, Andrea Černianska, Daniela Miklovičová, Jana Kostolanská
Background: Acute pyelonephritis is a frequent and serious disease of childhood. The aim of our study was to find out what is the statement value of N-acetyl-β-D-glucosaminidase/creatinine (NAG/creatinine) in diagnostics of acute pyelonephritis. Patient collection and methods: We observed the collection of 61 children (47 girls, 14 boys) at the age of 0-19 years (age average 4.4 years) with 1st attack of acute pyelonephritis. In patients we evaluated the level of C-reactive protein (CRP) and the amount of leucocytes in blood and the presence of leucocytes and bacteriuria in urine. At the same time the level of NAG/creatinine was evaluated in the urine of 39 patients. We compared these parameters with the values from control collection of 29 healthy children. Results: The children with pyelonephritis showed significantly higher number of leucocytes and higher values of CRP and NAG/creatinine than in the children in the control group. Conclusion: Regarding our results we are recommending to consider the examination of NAG/creatinine mainly in ambiguous cases of acute pyelonephritis and in the monitoring of treatment success.