Miloš Jeseňák1, Zuzana Havlíčeková1, Gabriela Bugová2, Peter Bánovčin1
PFAPA syndrome is an autoinflammatory disease of unknown etiology with possible contribution of genetic factors. The clinical picture is characterised by periodic fever, aphthous stomatitis, pharyngitis and neck lymphadenitis or some other rarer sypmtoms (joint or muscle pain, abdominal pain). Diagnosis is established by the exclusion of the different conditions associated with fever and through the complex evaluation of clinical symptoms. The treatment consists from the application of corticosteroids in single-dose. PFAPA syndrome is benign, self-limiting disease with spontaneously resolves with an increasing age of the patients without any consequences.