Zuzana Michnová, Jarmila Vojtková, Peter Ďurdík, Miriam Čiljaková
Background: Diabetes mellitus type 1 (DM1) is one of the most frequent and consequential chronic metabolic disease in children. Standard methods for evaluating of the compensation of diabetes are measurement of glycaemia and glycated hemoglobin (HbA1c). The estimation of carbon monoxide in exhaled breath (FeCO) is seen to be a new method for monitoring to the compensation of diabetes, oxidative stress and subclinical inflammation.
Aims of our study were
1) to determine the level of exhaled carbon monoxide in children with DM1 and compare it with the level of carbon mon-
oxide in control group of healthy children,
2) to estimate the relation between FeCO and parameters of metabolic com-
pensation, anthropometric and time parameters.
Patients: Our group consists of 108 children (58 had diabetes mellitus type 1 and 50 were control group of the healthy ones).
Methods: In each child we measured the carbon monoxide in exhaled breath by the electrochemical analysator, also we performed other measurements.
Results: The level of exhaled carbon monoxide was higher in diabetic part of population compared to healthy children (p=0.448), but the difference didn’t reach the level of statistical significance. Boys with DM1 had nonsignificantly higher FeCO than healthy boys (p=0.488), and also diabetic girls had nonsignificantly higher FeCO compare to healthy girls (p=0.710). Comparing subgroups of boys and girls with DM1 we didn’t record the difference in FeCO (p=0.660). In diabetic population we found significant correlation between FeCO and the age (rs=0.423, p <0.01) and BMI of children (rs=0.287, p <0.05), between FeCO and serum bilirubin level (rs=0.309, p <0.05) and a concentration of c-peptide (rs=0.263, p <0.05) and between FeCO and spirometric parameter FVC (rs=0.284, p <0.05).
Conclusions: Presumed correlations between FeCO and levels of glycaemia and glycated hemoglobin and between Fe-CO and the duration of diabetes we didn’t confirm. It is necessary to provide further studies to investigate the contribution of this new metod to the management of DM1 more precisely.