Ľubica Jakušová, Lenka Šofranková, Silvia Javorková, Darina Kružliaková, Miloš Jeseňák, Zuzana Havlíčeková, Zuzana Michnová, Peter Bánovčin
From among all the substances entering the gastrointestinal tract some are broken down and absorbed, others just pass through. In some circumstances these macromolecular substances can also be absorbed and act as antigens. A massive absorption of these macromolecules is prevented by intestinal mucosa, which acts as a barrier. The intestinal barrier consists of immunological and non-immunological protective mechanisms. A breach of any of its components causes increase in intestinal permeability with consequent activation of immune system. Lactulose- mannitol test (L/M test) is a non-invasive method of evaluation of intestinal permeability. It is a suitable method in diagnostics of cow’s milk protein allergy especially in infants with non-IgE allergic reaction.