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Časopis Neurology – Článok Magnetic resonance and its importance in the diagnosis of sclerosis multiplex (SM)

Neurology

Reviewed, postgraduate scietific medical journal.
Period 3x per year
1336-8621
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Neurology
Neurology
Reviewed, postgraduate scietific medical journal.
Period 3x per year
Téma: Overview works

Magnetic resonance and its importance in the diagnosis of sclerosis multiplex (SM)

Marek Tarčák, Veronika Vajdová

Sclerosis multiplex (SM) is a disease of the central nervous system (CNS) characterized with the inflammation, demyelination and neurodegeneration and it is very often a non-traumatic cause of neurological disability in young people(1). Episodes of focal infiltration of nervous issues with lymphocytes with subsequent destruction of myelin and axons are typical(2). The disease presents in each patient individually and while one group of patients reaches through their life a low score of disability (expressed with Kurtze scale of disability, Expand Disability Status Score - EDSS), others suffering from aggressive SM form reach a high EDSS in a relatively short time. In the pathogenesis of the disease many mechanisms are applied, which do not cause just local damage of the tissue but also lead to an important reduction of the parenchyma in the brain and spinal cord and finally to a permanent disability of a patient.
At present, brain and spinal cord imaging with magnetic resonance (MRI) has a significant role in the differential SM diagnosis, in monitoring of the activities of the disease itself, in the choice of a suitable therapy for a patient and evaluation of its effectiveness, in early detection of adverse effects of the treatment and in determination of the diagnosis. MRI examination is characterized by high sensitivity for early detection of the disease. However, the specificity of the examination is low. In patients with Clinically Isolated Syndromes (CIS) as optic neuritis, the syndrome of the brain stem or syndrome of the spinal cord, MRI might support or replace clinical manifestations based on the evaluation of the presence of demyelination lesions in the development of the disease. Not each CIS progresses to SM; however, the presence of T2 hyper intensive lesions on the MRI examination is related to the higher risk of SM origination and gradual disability. The MRI examination is also a key one in the exclusion of other diseases, which might simulate SM in the clinical picture(3,4).

Neurológia 2019; 14 (2): 79-81

Ročník 2019  Témy časopisu Neurology 2 / 2019

Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
doc. MUDr. Miroslav Brozman, CSc.

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doc. MUDr. Eleonóra Klímová, CSc.
doc. MUDr. Pavol Kučera, PhD.
MUDr. Marian Kuchar, PhD.
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MUDr. Vladimír Nosáľ, PhD.
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prof. MUDr. Karel Šonka, DrSc.
doc. MUDr. Peter Špalek, PhD.
Dr. Milan R. Voško, PhD.

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1. Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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Period 3x per year
1336-8621
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Neurology
Neurology
Reviewed, postgraduate scietific medical journal.
Period 3x per year