Miloš Jeseňák, Janka Vyšehradská, Zuzana Michnová, Peter Bánovčin
Selective IgA deficiency (SIgAD) is the most common primary human immunodeficiency with the prevalence of 1 : 163 – 1 : 3040. SIgAD is a heterogeneous syndrome with various pathogenetic mechanisms important in its development. Persons with SIgAD are usually asymptomatic. The most common diseases are recurrent infections of respiratory tract. SIgAD could be also associated with some allergic, gastrointestinal, oncological and autoimmune diseases of various organs and tissues. Causal therapy doesn’t exist. Associated diseases should be treated in the same way as in patients without SIgAD.