Miloš Jeseňák, Zuzana Rennerová, Peter Bánovčin
Predominantly humoral primary immunodeficiencies are clinically the most frequent inherited immunodeficiencies (approximately 70 % of all PID). The four most frequent PID are also from this group: selective deficiency of IgA, selective deficiency of IgG subclass, transient hypogammaglobulinemia of infancy and the deficiency of specific antibodies (against polysaccharide antigens). Most patients with these frequent immune diseases are asymptomatic during the whole life. Clinically the most important disease from humoral PID is common variable immunodeficiency which is characterized by decreased serum level of immunoglobulins (especially IgG and IgA) together with variable onset of clinical symptoms. The unique efficient therapy of these PIDs is regular intravenous or subcutaneous substitution of immunoglobulins. The infectious complication should be treated soon and adequately with appropriate antibiotics, and in indicated cases, also prophylactic antibiotic treatment is recommended.