Isoprinosine (Methisoprinolum) is an inosine acedoben dimepranol (inosine pranobex), a synthetic purine derivate with immunomodulatory and antiviral properties. Isoprinosine treatment is used in children in many clinical conditions in which acute, subacute and chronic viral infections, mainly herpetic infections have been associated with a reduced host immune response. The strategy of the treatment depends on the type and severity of infection and laboratory results. This may be episodic, cyclic or combined with other immunomodulatory drugs or surgery. Early diagnosis and treatment of the disease by Isoprinosine are also essential.