Miloš Jeseňák, Zuzana Rennerová, Zuzana Vojtušová, Renáta Kuniaková, Peter Bánovčin
Biologically active polysaccharides (BAP) present the group of active substances of natural origin with a proved pleiotropic immunomodulation effect. Their efficacy was confirmed in the therapy and prevention of various infectious diseases, secondary immune defects and also oncologic disorders. Allergic diseases belong to the most frequent diseases and their prevalence is still increasing. They develop as a consequence of the immune system dysregulation, especially on the basis of the failure of TH1/TH2 lymphocyte equilibrium towards TH2 response. New therapeutic approaches in the treatment of immunopathological conditions (e.g. allergic or oncologic) are directed to the restoration of the equilibrium among different T lymphocyte subpopulations. Based on in vitro experiments and also on the animal and human clinical studies there are many evidences for the importance of BAP in the treatment and also prevention of allergic diseases what opens new perspectives on the use of this widespread and popular group of natural substances.