Miroslav Šašinka, Katarína Furková, Alica Nogeová
Nonalcoholic fatty liver disease has become the most common chronic liver disease in childhood. It comprises a wide spectrum of liver damage ranging from simple steatosis to diffuse fibrosis and cirrhosis. Modern trends of treatment follow the existing knowledge of the pathogenesis of a disease, but they are still incomplete and for that reason the therapy is still empiric. Many therapeutic trials evaluate only biochemical changes, without histological verification, and furthermore there are far less studies in children than in adults. In therapy the authors estimate possibilities of weight reduction, insulin resistance reduction by insulin-sensitizer drugs, improvement of dyslipidemia, oxidation stress treatment, improvement of intestinal dysmicrobia, using of cytoprotective agents able to stop apoptosis and renin-angiotensin system activity reduction.