Recurrent abortion is defined as the occurrence of three or more clinically recognized pregnancy losses before 20th week from the last menstrual period. It occurs in about 1 in 300 pregnancies. Primary recurrent abortion in diagnosed in women with the history of only abortions, while secondary is reserved for those that delivered a viable fetus. The etiology may be due to genetic factors, anatomic abnormalities, endocrine disturbances, maternal infections, immunologic phenomena and other less frequent pathologies. The evaluation is preconceptional and consists of medical history, physical examination and laboratory evaluation, and postconceptional (beta hCG and ultrasound). Therapy is often difficult and consists of genetic abnormalities approaches, correction of anatomic abnormalities, endocrine disorders, infection and immunologic factors treatment and psychological support. The prognosis of viable fetus delivery ranges from 60 to 76 %.