Vladimír Šišovský, Ľudovít Danihel, Michal Palkovič, Beata Bučeková, Martin Redecha, Miroslav Korbeľ, Zuzana Nižňanská, Vanda Repiská, Alžbeta Molnárová, Ivica Bartošová
Histomorphological appearance of endometrium and content of some proteins in it is changing in relation to a biological age of a woman. Important changes are arising mainly in tumour processes. In this work we focused on the expression of estrogen α receptor in clear cell endometrial carcinoma. We examined immunohistochemically 10 samples with normal proliferative endometrium and 10 samples with clear cell endometrial carcinoma. The expression of estrogen α receptor was high in proliferative endometrium. The expression of estrogen α receptor was not found in clear cell endometrial carcinoma that corresponded with the worse clinical behaviour of the tumour. In accordance with other publications we are stating that the expression of this protein is an important prognostic marker of endometrial carcinoma. Therefore evaluation of this protein by immunohistochemistry is an important factor with implications for clinical practice.