Monika Drakulová, Libuša Ceizelová
A set of mutual interactions is formed during the common life of a mother and her fetus involving both positive and negative factors including also alloimmunization. The basis of perinatal alloimmune cytopenia is characterised by formation of alloimmune antibodies against erythrocytes (neonatal hemolytic disease), against neutrophils (neonatal alloimmune neutropenia), or against thrombocytes (neonatal alloimmune thrombocytopenia). They develop depending on pregnancy accompanied by the incompatibility of the mother and fetus antigens. Fetomaternal hemorrhage results in stimulation of the mother’s immune apparatus and formation of specific antibodies of the IgG class, which pass through the placenta into the fetal circulation where they can cause a shorter life span of blood cells. Fetal affliction ranges from the laboratory signs of alloimmunization even to severe clinical conditions, which can result in death of the fetus or newborn.