Restless legs syndrome (RLS) is a neurological disorder characterized by a compelling urge to move limbs. This is caused by disturbing sensations within the legs which is usually present during rest or at night. Direct consequences interfering with patients´ daily functioning and quality of life are discomfort, serious sleep disturbance, and fatigue. Prevalence of RLS is 7 - 10 %, and 2.7 % individuals in general population require daily treatment. The role of subtle dopamine deficiency and central iron defect seem to be crucial in the patophysiology. Many patients do not require medication, and symptoms often can be relieved with good sleep hygiene and avoidance of medications and factors that provoke symptoms. Several classes of medications are helpful, but dopaminergic therapy appears to be most effective.