Peter Špalek, Ivan Martinka, František Jurčaga, Denis Richter, Eva Hanáčková
Miller Fisher syndrome (MFS) is a localized variant of Guillain-Barré syndrome (GBS), characterized by ophthalmoplegia, areflexia and ataxia. Anti-GQ1b IgG antibodies are present in MFS and are believed to be pathogenic. Presynaptic neural membranes and perisynaptic Schwann cells are targets for anti-GQ1b antibody attack. We report one patient with localized MFS and two patients with overlapping form of MFS and GBS. This article focuses on pathogenesis, clinical spectrum, diagnostic criteria, differential diagnosis and treatment of MFS. Both plasmapheresis and intravenous immunoglobulin are effective first-line therapies, especially in cases of MFS with overlapping GBS.