Stanislav Šutovský1, Andrej Blaho1, Branislav Kollár1, Pavol Šiarnik1, Jozef Dragašek2, Ľubomíra Izáková3, Peter Turčáni1
Alzheimer’s disease is defined as a clinico-pathological entity. Primary diagnostic criteria were worked out in 1984 and those reflected the contemporary level of knowledge. Biomarkers and neuroimaging were not included in the protocol. This clinical definition and diagnostic criteria were gradually overcome and there has been an increasing need for redefinition and a new clinical concept. Recent progress in the use of reliable biomarkers has stimulated a development of new research criteria that reconceptualise the diagnosis both around specific pattern of cognitive changes as well as biological evidence of Alzheimer‘s pathology. In this paper we try to summarise newly revised diagnostic concept with regard to redefined clinical and biological particularities.