Lucia Turianová1, Katarína Lopušná1, Igor Stankovič3, Lukáš Greguš3, Peter Kabát1,2, Ingeborg Režuchová2
Infections of the central nervous system caused by viruses cause clinically significant and often life threatening diseases. Many factors affect the development of those infections: patient´s general health condition, the way the virus enters the body and last but not least, it depends on the ability of the host immune system to respond on virus infection by antibody production. In this regard, vaccination, as the pre-exposure prophylaxis, has an important role by protecting an individual against outbreak of infectious viral disease very successfully. The aim of the work is to give a comprehensive picture of two most frequently occurring neuropathogenic viruses in Slovakia, tick-borne encephalitis virus, and herpes simplex virus-1, about their pathogenesis, treatment and prophylaxis, supported by casuistry of two individual cases.