Stanislav Šutovský1, Pavol Šiarnik1, Branislav Kollár1, Andrea Škultéty-Szárazová1, Miroslav Žigrai2, Adriana Reptová3, Peter Turčáni1
Intracerebral hemorrhage (ICH) represents 12-15 % of all cases of stroke. Clinical presentation includes suden onset and usually more severe neurologic deficit than in case of ischemic stroke. From a genetic point of view intracerebral hemorrhage can be devided in to two major groups. The first one comprises intracerebral hemorrhage with polygenic genetic background. This group includes more than 90 % of all cases of ICH and to the genetic predisposition contribute lot of genes with small effect. Genetics background of this group is heterogenous and covers the genetic background of conventional risk factors of ICH – arterial hypertension, hypercholesterolemia, diabetes mellitus and obesity. A substantial role plays the cooperation of genetical predisposition and enviromental factors. Second group is represented by monogenic syndromes of ICH. This group constitutes less than 10 % of cases of ICH, but genetic factors play a key role. Intracerebral hemorrhage is considered main or leading manifestation of monogenic syndrome. In our article we try to summarise current view on the genetics of intracerebral hemorrhage. We drow our atention to both groups but more particullary we focus on monogenic and rare causes of ICH.