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Časopis Clinical urology – Článok Prostate carcinoma and neuroendocrine differentiation

Clinical urology

Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Téma: 

Prostate carcinoma and neuroendocrine differentiation

Karol Kajo, Vladimír Bartoš, Lukáš Plank

Objective: Neuroendocrine (NE) differentiation in prostate cancer (CaP) is one of important parameters in the biopsy examination of tumor tissue. Although this phenomenon is present at least focally virtually in all cases of CaP, tumors may show divergent differentiation towards a NE phenotype. Material and methods: A literature review of current status of neuroendocrine differentiation and its importance in the prostate carcinoma. Results: Generally, NE differentiation of CaP occurs in three different forms: as a. small cell carcinoma, b. carcinoid or carcinoid- like tumors, and c. focal NE differentiation in conventional acinar adenocarcinoma. Especially, this last type is very frequent, if not ubiquitous phenomenon, and reflects tumor cell heterogeneity mimicking the normal differentiation process. The prognostic significance of focal NE differentiation remains controversial but current evidence suggests an influence on prognosis related to hormone-resistant tumors and a role in the conversion to a hormone-resistant clinical manifestation. All CaPs originate as an androgen-dependent hyperproliferation of the epithelial cells of the gland and they evolve in an androgen- independent, highly aggressive cancer for which no successful therapy is available to date. Conclusion: Therefore, based on these facts, there is increase need of continual clinico-pathological studies and trials for development of adequate treatment strategies, targeting NE differentiation that may hold the solution for patients with advanced hormone refractory prostate cancer.

Klin. urol. 2007; 3 (3) 139 - 143
CELÝ OBSAH ČLÁNKU JE DOSTUPNÝ IBA PRE PRIHLÁSENÝCH PREDPLATITEĽOV Prihlásiť sa

Ročník 2007  Témy časopisu Clinical urology 3 / 2007

Case Studies

Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ján Kliment, CSc.

MEMBERS OF THE EDITORIAL BOARD
prof. Andrzej Borówka, M.D., PhD.
prof. MUDr. Ján Breza, DrSc.
prof. MUDr. Peter Bujdák, PhD.
prof. MUDr. Tomáš Hanuš, DrSc.
doc. MUDr. Ladislav Jarolím, CSc.
doc. MUDr. Ján Ľupták, PhD.
doc. MUDr. Jozef Marenčák, PhD.
doc. MUDr. Ivan Minčík, PhD.
prof. MUDr. Dalibor Ondruš, DrSc.
prof. Imre Romics, M.D., PhD.
doc. MUDr. Vladimír Študent, PhD.
prof. MUDr. Ján Švihra, PhD.
prof. MUDr. Ladislav Valanský, PhD.
doc. MUDr. František Záťura, PhD.
MUDr. Peter Zvara, PhD.

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prof. MUDr. Ján Švihra, PhD.

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Ing. Danica Paulenová
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Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett´ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285: 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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Which of following factors is not related to rosacea?
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b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are reviewed.

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Send contributions in the e-mail to the address: paulenova@amedi.sk
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year