Hana Šiffnerová, Dana Králová
Objective: The work is aimed at the occurrence of secondary malignancies after therapy for primary testicular tumours. The target of the work was determination of the number and type of secondary tumours, their effect on the survival and comparison of relative risk of the origination of secondary tumours depending on particular treatment modalities. Material and methods: Total of 313 patients with testicular tumours were assessed, who experienced orchiectomy in 1968 to 1998 with subsequent irradiation, chemotherapy or combination of the two modalities. Statistical methods comprised the survival analysis by Kaplan-Meier, the Fisher test, squared Chi test, log-rank test and determination of relative risks. Results: Total of 22 secondary tumours, i.e. 7 % were found in the group. The relative risk of the secondary malignancy development was of 1.04. The median time till the secondary tumour occurrence was of 143 months (41 - 418 months). Total of 7 tumours, i.e. 2,2 %, were found in the contralateral testicle with the median time till the secondary tumour occurrence of 32 months (1 - 65 months). Total of 213 patients were subjected to radiotherapy, which was associated with enhanced risk of the secondary tumour development (RR = 8.38), especially for tumour of the pancreas, melanoblastoma and tumour of the rectosigmoideum. The risk in 100 patients treated by chemotherapy was low (RR = 0.38). Conclusion: Most patients with testicular tumours have long-term prognosis and thus, it is desirable to know the risk of secondary malignancies and to include it into plan of long-term subsequent follow-up.