Boris Krahulec, Lujza Štrbová
Diabetic foot is defined as an infection, ulceration and/or destruction of deep tissues associated with neurological abnormalities and various degrees of peripheral vascular disease in the lower limb, based upon the WHO definition. Lower limb ischaemia and neuropathy together with bone deformities and trauma are leading factors for foot ulcerations. In clinical practice education is very important for the patient, while it is valuable intervention in the prevention of diabetic foot problems. Therapeutic options are good glycaemic control, atherosclerotic risk factors modification, walking programs. Other specific features of treatment are haemodilution, vasoactive drugs, acetylosalicylic acid, anticoagulation therapy. Revascularization should be carefully considered. If neuropathy is present, pathogenic treatment is α-lipoic acid, in the case of infection antibiotics should be used.