Heart failure (HF) is one of the most problematic issue of cardiology. Prevalence of HF is increasing and it is supposed to increase to the half of the century. HF is the commonest cause of hospitalization. HF in women has specific features from the aspect of etiology, pathogenesis, prognosis and probably therapy as well. Typically HF develops in a woman after 70 with known arterial hypertension and diabetes. Systolic function of the left ventricle is preserved, clinically exertion dyspnoe dominates. The article presents a review of differences of particular aspects of heart failure between men and women and opens the question of potential differences in optimal therapeutical approach.