Martin Studenčan
The key importance of antithrombotic treatment in interventional revascularization procedures is related to the pathophysiology of the coronary heart disease (CHD), where atherothrombosis plays a key role in acute coronary syndrome (ACS) in particular. It is also related to the fact that a metal stent is implanted in the coronary artery in percutaneous coronary intervention (PCI), and the stent itself continues to increase the risk of atherothrombotic complication. When a stent is implanted, dilatation of the artery and intima microdissection occur, which stimulates thrombogenesis together with the strange nature of the metal material. Unfortunately, the high efficacy of modern antithrombotic treatment, on the other hand, may endanger a patient with severe hemorrhagic complications, for example in gastrointestinal tract or central nervous system. Therefore, the optimal antithrombotic regime must take into account clinical circumstances (acute or chronic condition), hemorrhagic risk level, or type of revascularization procedure (PCI or CABG).
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