Peter Ďurdík, Jana Kecerová, Miriam Čiljaková, Viera Ďurdíková, Silvia Varechová, Peter Bánovčin
Diabetic neuropathy belongs to the most important chronic complication of diabetes mellitus. The nerve disturbance first in non-myelinated autonomic nerves followed by sensitive and motor nerves is the pathomechanism. The first symptoms are manifested already in children with diabetes mellitus. Diabetic neuropathy, especially subclinical diabetic neuropathy, is responsible for higher mortality and morbidity of these patients. The main clinical symptoms are tachycardia, neurocirculatory instability, dysphagia, gastroparesis, constipation, urination dysfunction and other. Subclinical diabetic neuropathy is possible to diagnose mainly by specific tests of autonomic nervous system. Measurement of heart rate variability, pupilar reflex, cough receptor sensitivity, electromyography and gene polymorphisms belong to most prospective tests.