Miroslava Kohútová, Miloš Jeseňák, Ľubica Jakušová, Lenka Šofranková, Otília Petrovičová, Peter Bánovčin
Histamine intolerance (later referred to as HIT) is a complex disease which has not been studied thoroughly to this day.
Reasons behind the development of HIT may be an excessive accumulation of exogenous or endogenous histamine in
organism and a disorder of metabolic degradation of histamine. The clinical picture of HIT consists of several non-specific
signs and symptoms that are often similar to allergic reactions. An effective diagnostic tool for HIT is still not available,
but the most often used method is to determine activity and concentration of diamine oxidase (DAO) in serum
and in biopsy sample from intestinal epithelium, whereas it is also possible to apply molecular genetic examination of
a gene for DAO in chosen cases. Only several studies aimed at histamine intolerance research have been carried out in