Róbert Dankovčík, Peter Urdzík, Radomír Hredzák
The study involved 494 women in the 1st trimester from 10+0 – 13+6 weeks of pregnancy in which the levels of PAPP-A were determined. Results of measuring, determining of levels of MoM percentils, regressive studies and median graphs enable to introduce PAPP-A as a new marker of chromosomal abnormalities in the 1st trimester into clinical practice. Serum levels of PAPP-A in Down`s syndrome are typically very low during the 1st trimester and thus suitable for screening. PAPP-A has been found to be the only clear placental product the level of which is in gravidity with Down`s syndrome lower.