Róbert Dankovčík; Alexander Ostró, Peter Urdzík, Igor Lazar, Radomír Hredzák
The aim of detailed sonographic examination of the foetus in the 2nd trimester is to detect structural and functional abnormalities of the foetus typical for chromosomal abnormalities. In Anglo-Saxon literature it is referred to as genetic ultrasound. If no markers of chromosomal abnormalities are found, the primary risk of aneuploids (age or biochemical) can be modified. AAURA score system enables to reduce the number of invasive interventions by 62 or 74 % in women (age indication for amniocentesis). In women older than 40 years neither negative genetic ultrasound nor AAURA score system can reduce the risk of chromosomal abnormality beneath the level 1 : 250 without cardiologic markers. The use of cardiologic markers can reduce the number of invasive interventions by 31 %.