Multiple myeloma is a malignant plasma cell disease. It accounts for about 1 % of all type of malignant diseases and slightly more than 10 % of hematological malignancies. The majority sign is production a monoclonal protein which may be demonstrated in the serum or/and urine. Skeletal radiology show osteolytic lesions and associated pain is characteristic. Multiple myeloma is an illness that reacts well to treatment which can result in period sof remission lasting for years. A pre-requisite for successful treatment is early diagnosis. In conjunction with neurologists, orthopedicians, radio diagnosticians and first line physicians.