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Časopis Neurology – Článok Myasthenia gravis – autoimmune spectrum and immunopathogenetic classification

Neurology

Reviewed, postgraduate scietific medical journal.
Period 3x per year
1336-8621
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Neurology
Neurology
Reviewed, postgraduate scietific medical journal.
Period 3x per year
Téma: Original Works

Myasthenia gravis – autoimmune spectrum and immunopathogenetic classification

Peter Špalek

Myasthenia gravis (MG) is defined as a disorder of the neuromuscular junction with fluctuating weakness of voluntary muscles associated with exhaustibility. MG is a heterogenous disorder with 4 distinct subgroups which differ immunologically, clinically and in responses to various treatments: 1. Seropositive MG (SPMG). 70-75 % MG patients have positive autoantibodies against nicotinic acetylcholine receptor (AChR). According to the different role of the human thymus for the immunopathogesis there are two forms of SPMG: A. SPMG associated with thymic lymphofollicular hyperplasia and young onset (< 45 years). B. SPMG associated with thymic atrophy and old onset (> 45 years). 2. Thymoma associated myasthenia gravis (TAMG). 10-15 % MG patients have SPMG with autoantibodies to AChR associated with thymoma and antibodies against titine. In TAMG there is an evidence of both central (thymic) and peripheral (extrathymic) immunopathogenesis. 3. Seronegative MG (SNMG) to AChR and positive antibodies against MuSK (muscle specific kinase) has 7 % of MG patients. 4. „Pure“ SNMG (no autoantibodies to AchR and to MuSK) has 8 % of MG patients. Treatment focuses on anticholinesterases, immunosuppressive agents, thymectomy, and short-term interventions such as plasmapheresis and intravenous immunoglobulin. These treatments, usually in combination, produce remission or marked improvement in about 90 % of MG patients. Treatment should be individualized and there is no single regimen that is appropriate for all patients.

Neurológia 2009; 4 (1): 25-30
CELÝ OBSAH ČLÁNKU JE DOSTUPNÝ IBA PRE PRIHLÁSENÝCH PREDPLATITEĽOV Prihlásiť sa

Ročník 2009  Témy časopisu Neurology 1 / 2009

Overview works

Original Works

Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
doc. MUDr. Miroslav Brozman, CSc.

MEMBERS OF THE EDITORIAL BOARD
MUDr. František Cibulčík, CSc.
doc. MUDr. Eleonóra Klímová, CSc.
doc. MUDr. Pavol Kučera, PhD.
MUDr. Marian Kuchar, PhD.
doc. MUDr. Robert Mikulík,Ph.D., FESO
MUDr. Vladimír Nosáľ, PhD.
MUDr. Ľubica Procházková, CSc.
prof. MUDr. Bruno Rudinský, CSc.
doc. MUDr. Daniel Šaňák, Ph.D.
doc. MUDr. David Školoudík, Ph.D., FESO
prof. MUDr. Karel Šonka, DrSc.
doc. MUDr. Peter Špalek, PhD.
Dr. Milan R. Voško, PhD.

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Eva Stachová
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Examples of citations:
1. Pitt B, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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Which of following factors is not related to rosacea?
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Send contributions in the e-mail to the address: stachova@amedi.sk
Period 3x per year
1336-8621
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Neurology
Neurology
Reviewed, postgraduate scietific medical journal.
Period 3x per year