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Časopis Clinical urology – Článok Oxidative damage to dna and prostate cancer

Clinical urology

Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Téma: 

Oxidative damage to dna and prostate cancer

Monika Kmeťová - Sivoňová1, Ľubica Stankovičová1, Marta Vilčková1, Dušan Dobrota1, Mária Kovalská1, Zuzana Tatarková1, Martina Pavlíková1, Ján Kliment2

Introduction and Aims: Reactive oxygen species (ROS) mediated DNA damage in addition to ineffective DNA repair mechanisms are well established lesions common to human cancers. DNA alterations like strand breaks, base modifications and DNA-protein cross linkages are all strongly implicated in the initiation stage of carcinogenesis. Major oxidative DNA damage product 8-oxo-7,8-dihydro-2´-deoxyguanosine (8-oxodG) is regarded as a potential biomarker of mutagenesis consequent to oxidative stress. The aim of the present study was to detect the DNA oxidative damage in prostate cancer and in healthy individuals to understand the mechanism, to monitor participation of the oxidative stress in the process of damage of biologically important molecules and in the process of carcinogenesis. Material and Methods: The study included 20 prostate cancer patients (mean ± SEM: 63.35 ± 1.8 years) and 20 control subjects (mean ± SEM: 65.95 ± 1.8 years) for the analysis of 8-oxodG using a modified single cell gel electrophoresis (Comet assay). The results were analysed with the Student’s paired t-test. Results: The levels of 8-oxodG were significantly higher (p < 0.05) in prostate cancer patients than in controls. There was a positive correlation between the levels of 8-oxodG and serum PSA levels and we have found no correlation between 8-oxodG and Gleason score in prostate cancer patients. Conclusions: Our results demonstrate that an increased rate of oxidative stress might play a role in the pathogenesis of prostate cancer as evidenced by a failure in the oxidant/antioxidant balance in favour of DNA damage.

Klin. urol. 2012; 8 (2-3): 90-94

Ročník 2012  Témy časopisu Clinical urology 2 / 2012

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The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year