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Časopis Clinical urology – Článok Evaluation of the proliferative activity in renal cell carcinoma – analysis of own cases

Clinical urology

Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year
Téma: 

Evaluation of the proliferative activity in renal cell carcinoma – analysis of own cases

Vladimír Bartoš1, Juraj Mikuláš2, Roman Mráz2

Aim: One of the molecular parameters, which reflects the biological behaviour of malignant neoplasms and also provides important prognostic information, is a proliferative activity of tumour cells. In submitted work, we focused on quantitative evaluation of proliferative activity in RCC and its potential relationship with other pathological variables of tumour. Material and methods: A study group consisted of 25 cases of primary RCC in various clinical stage of disease; they were obtained from 25 patients. Proliferative activity of tumour cells was immunohistochemically detected by the antibody against Ki-67 antigen and quantitatively defined as Ki-67 index. Results: In a group of RCCs assessed, Ki-67 index varied between 0-5 % (mean value 1.7 %). Three carcinomas did not contain any ‘Ki-67 positive’ tumour cells (Ki-67 index 0 %) and another five had Ki-67 index less than 1 %. We failed to recognise a tendency of increasing frequency of more unfavourable pathological findings with increasing Ki-67 index. Advanced cancers with regional lymph nodes metastases did not have Ki-67 index higher than 1 %. Conclusion: In concordance with the literature data we found that carcinoma of kidney exhibited a low proliferative activity of tumour cells. Moreover, an evidence of Ki-67 antigen expression can be completely missing in some cases. For this reason, a histological evaluation of Ki-67 index has a limited benefit in distinguishing of certain benign epithelial renal tumours from RCC and maybe it is also the cause of the controversial views about prognostic impact of proliferative activity in this oncological disorder.

Klin. urol. 2013; 9 (2-3): 97-101
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doc. MUDr. Vladimír Študent, PhD.
prof. MUDr. Ján Švihra, PhD.
prof. MUDr. Ladislav Valanský, PhD.
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MUDr. Peter Zvara, PhD.

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Period 3x per year
1336-7579
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Clinical urology
Clinical urology
Postgraduate scientific medical journal. Magazine Slovak Association of Urology.
Period 3x per year