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Časopis Slovak Gynecology and Obstetrics – Článok ANALYSIS OF CIRCULATING TUMOUR DNA IN PATIENTS WITH BREAST CANCER – PILOT STUDY

Slovak Gynecology and Obstetrics

Magazine Slovak Association of Gynecology and Obstetrics
Period 4x per year
1335-0862
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Slovak Gynecology and Obstetrics
Slovak Gynecology and Obstetrics
Magazine Slovak Association of Gynecology and Obstetrics
Period 4x per year
Téma: Original works

ANALYSIS OF CIRCULATING TUMOUR DNA IN PATIENTS WITH BREAST CANCER – PILOT STUDY

K. Zelinová, M. Jagelková, Z. Laučeková, M. Grendár, K. Dókuš

The breast cancer is the most commonly diagnosed cancer in the world and is the leading
cause of cancer deaths among women. Genomic sequencing provides the opportunity
for a deeper understanding of the cancer biology and allows the identification
of tumour-specific genomic changes that have potential to be used in the diagnosis
and therapy of malignancies. The sequential examination of free circulating tumour
DNA (ctDNA) provides comprehensive information on genetic changes in a primary
tumour, its metastases, and can identify new mutations that originate during oncological
treatment. We detected somatic gene mutations with a pathogenic effect in
patients with breast cancer, with the TP53 and FBXW7 being the most frequently affected
genes. In most cases, these changes were single nucleotide substitutions with
a missense mutation effect.

Slov. Gynek. Pôrod., 24, 2017, s. 173 – 176
CELÝ OBSAH ČLÁNKU JE DOSTUPNÝ IBA PRE PRIHLÁSENÝCH PREDPLATITEĽOV Prihlásiť sa

Ročník 2017  Témy časopisu Slovak Gynecology and Obstetrics 4 / 2017

Original works

Case study

Nie sú dostupné žiadne voľne dostupné články
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doc. MUDr. Igor Rusňák, PhD.
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Period 4x per year
1335-0862
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Slovak Gynecology and Obstetrics
Slovak Gynecology and Obstetrics
Magazine Slovak Association of Gynecology and Obstetrics
Period 4x per year