Janka Božíková, Michal Demeter, Peter Bánovčin, Rudolf Hyrdel
Crohn´s disease is a non-specific inflammatory bowel disease characterized by chronic course with periods of non-predictive relapses and remissions. Aetiology and genesis of the disease is unkonown. varied symptomatology with extraintestinal manifestations can be a great diagnostic problem. Biological therapy has significantly moved the borders of therapeutic possibilities, nevertheless, the disease is still medicamentously and surgically uncurable. Incidence of MC is increasing, the course of the disease is chronic and complicated requiring expansive medicamentous therapy and repeated surgical interventions. It is a severe problem not only for the patient but also a socio-medico-economical problem worldwide. The authors deal with problems of the disease with the emphasis on genetics, pathogenesis, clinical picture, diagnostics and therapeutic procedures.