Alexandra Danningerová Molnárová, Marián Bátovský, Igor Páv
Common variable immunodeficiency (CVID) is a disease characterized by low to undetectable levels of serum immunoglobulins and increased susceptibility of the organism to infections. It is the most common primary immunodeficiency. CVID is a heterogeneous group of immunological diseases of unknown aetiology, characterized by impaired antibody responses. The cause of the disease is unknown. The clinical picture of the disease and even the severity varies from patient to patient, that’s why it is called variable. It manifests itself as a recurrent respiratory infection, digestive problems in terms of diarrhoea and abdominal pain and haematological abnormalities such as anaemia and thrombocytopenia are present. The aim of the described case reports is to point out that CVID is a disease with a variable actual picture that may be present, among others, with gastrointestinal involvement, and patients are at higher risk than healthy population of developing malignancies, which is often a lympho-proliferative malignancy.