Nonspecific inflammatory bowel disease, or Crohn’s disease and ulcerative colitis, are among the diseases that mainly affect people in working age. Affected patients may have complications solving of which is often surgical and by its course, symptoms as well as by complications it deteriorates their quality of life. In the classical, so-called “step up” treatment procedure biological therapy comes just after failure of other conventional treatments. Recently it appears that earlier inclusion of biological therapy in the therapeutical process may positively influence the course of the disease in some patients. This approach is the so-called “top down” process.