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Časopis Gastroenterology for practice – Článok Liver disease and type 1 diabetes mellitus

Gastroenterology for practice

Reviewed, postgraduate scientific medical journal.
Period 4x per year
ISSN:1336–1473
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Gastroenterology for practice
Gastroenterology for practice
Reviewed, postgraduate scientific medical journal.
Period 4x per year
Predplatné
Téma: 

Liver disease and type 1 diabetes mellitus

Zuzana Michnová, Renata Szépeová, Miriam Čiljaková, Lýdia Zúbriková, Peter Bánovčin st.

Liver disease and type 1 diabetes mellitus
Background: liver plays an important role in the regulation of carbohydrate metabolism. Type 1 diabetes mellitus
(DM1) is one of the most frequent chronic metabolic diseases in children. Diabetes mellitus affects all organ systems
including the gastrointestinal tract. According to the literature, the prevalence of hepatopathy in patients with DM1
ranges between 17-100 %, however, the majority of the studies were performed in adults. Non-alcoholic fatty liver disease
and hepatic glycogenosis (Mauriac syndrome) are two most frequent liver diseases occurring as a consequence
of diabetes mellitus, mainly resulting from inadequate compensation. We aimed to investigate levels of serum liver
enzymes, glycaemic control and to estimate the incidence of ultrasound changes of the liver in children with DM1.
Methods: in the study, we enrolled 72 children with DM1 (29 boys, 40.27% and 43 girls, 59.72 %) who were hospitalized
in 2015 at the Department of Paediatrics, University Hospital in Martin to perform control testing, adjust insulin
therapy, or set an insulin pump for therapy.
All subjects underwent the panel of standard biochemical blood tests: fasting glucose level, fasting lipid profile, liver
enzymes, creatinine, total bilirubin, glycated haemoglobin, C-peptide, microalbuminuria and ultrasonographic examination
of the abdomen.
Results: the median age was 13.42 years (IQR: 10.50-18.50 years). The average duration of diabetes in the population
was 5.30 years (IQR: 1.80-8.30 years). Diabetes compensation was unsatisfactory, HbA1c was 10.19% (IQR:
6.50-16.40%). There were found 23.61% of patients having one or more liver abnormalities, hepatomegaly in 12.5 %,
changes in echogenicity of the liver parenchyma in 11.11 % and liver enzymes elevation in 8.33 %. DM1 patients with
abnormal hepatic ultrasound had significantly higher HbA1c (p= 0.05), fasting glucose level was not significantly higher
(p= 0.16) than those with normal findings. Based on clinical and laboratory findings in 2 children Mauriac syndrome
diagnosis was assumed; in one case acquired liver glycogen was subsequently confirmed by biopsy examination.
Discussion: According to the literature and results of our study, the hyperechogenic liver and/or hepatomegaly are
not uncommon in children with DM1. Hepatic glycogenosis is a rare complication of poorly controlled DM1 characterized
by elevated liver enzymes, hepatomegaly, and glycogen accumulation in hepatocytes.
Conclusions: hepatic abnormalities are frequent in paediatric patients with DM1, and they are usually related with
long-term unsatisfactory metabolic control of the disease.

diabetes mellitus, hepatopathy, steatosis, Mauriac syndrome
Gastroenterol. prax 2018; 17 (3): 111 – 116

Ročník 2018  Témy časopisu Gastroenterology for practice 3 / 2018

Katarína Gombošová, Emeše Majorová, Stella Majlingová, Milan Kuchta
Zuzana Michnová, Renata Szépeová, Miriam Čiljaková, Lýdia Zúbriková, Peter Bánovčin st.
Miroslava Petrášová, Emeše Majorová
Miroslava Petrášová, Milan Kuchta, Emeše Majorová

Case studies

Michaela Dzuriková
Júlia Zapotocká, Mária Zakuciová, Karim Benhatchi

Overview works

Tomáš Šálek
Peter Minárik, Jozef Golian, Peter Chlebo
Michal Brunčák
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Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Rudolf Hyrdel, CSc.

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Marian Bátovský, CSc., mim. prof. SZU
prof. MUDr. Juraj Bober, CSc.
MUDr. Ivan Bunganič
prof. MUDr. Petr Dítě, DrSc.
doc. MUDr. Martin Huorka, CSc.
doc. MUDr. Peter Makovník, CSc.
MUDr. Juraj Májek, PhD.
prof. MUDr. Peter Mlkvý, CSc.
MUDr. Tomáš Šálek
MUDr. Renata Szépeová, PhD.
prof. MUDr. Anton Vavrečka, CSc.
MUDr. Mária Zakuciová

EDITOR-IN-CHIEF
Ing. Danica Paulenová
e-mail: paulenova@amedi.sk

GRAPHIC LAYOUT AND TYPESETTING
Lucia Vecseiová
e-mail: dtp@amedi.sk 

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PROFESSIONAL PROOFREADING
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LANGUAGE PROOFREADING
Mgr. Eva Doktorová

PROOFREADING OF ENGLISH TEXTS
Mgr. Jana Bábelová
SECTIONS

SURVEY WORKS
The latest knowledge on disease and disease groups aetiology, pathogenesis, diagnoses and therapy.
Maximum size is 8 pages (font size 12, line spacing 1.5) with maximum five pictures (graphs). In case of more extensive theme elaboration it is possible to divide the paper to several parts after agreement with editorial office. Write the article with focus on its practical use for gastroenerologists and specialists from other disciplines interested in gastroenterology.

CASE STUDY
Maximum extent is 7 pages. Structuring: summary, introduction, case study, discussion, conclusion, bibliography.

DIAGNOSTIC AND THERAPEUTICAL ALGORITHMS
Diagnosis and therapy processed into tables and schemes, with minimum text, with emphasis on conciseness and clarity.

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Write the paper on computer in any common text editor.
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MANUSCRIPT REQUIREMENTS

1. An accurate paper title, names and surnames of all authors including titles, authors` workplace. The first author address including the phone number, fax and e-mail address.
2. Summary - concise content summary in the extent maximum 10 lines (only at overview papers, case studies). Write in 1st or 3rd person singular or plural (unify according the type of an article).
3. Key words - in the extent of 3-6 (only for overview papers and case studies).
4. English translation: paper title, summary, key words (only at overview papers and case studies)
5. Text
If you insert pictures into a document, send also their original files in "jpg" format, create graphs in Excel and send also their original files. If you send photo documentation via post office, please, send just high-class originals. Mark each original by a number, under which it is mentioned in the text. Write in 1st or 3rd person singular or plural (unify according the type of an article).
6. Bibliography
Citations are numbered chronologically in bold, references in the text are stated by the number of citations in parentheses. Use maximum 20 citations.

Examples of citations:
1. Vaughan TL, Davis S, Kristal A, et al. Obesity, alcohol and tobacco risk factors for cancers of esophagus and gastric cardia :adenocarcinoma versus squamous cell carcinoma Cancer Epidemiol Biomarkers Prev 1995; 4: 85-92.
2. Gao YT, McLaughlin JT, Gridley T, et al. Risk factors for esophageal cancer in Shanghai, China. Role of diet and nutrients. Int J Cancer 1994; 58: 197-202.
3. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett´ esophagus? Gastroenterology 2000; 119: 333-338.

Do not use dots after first names in citations. Do not use colon but dot after names of authors. Use semi-colon after the year of publishing, colon is before pages. If an author is one, two or three - it is necessary to state all. If there are more than three authors it is necessary to write first three and "et all", in Slovak and Czech citations "a spol."


AUTODIDACTIC TEST

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are reviewed.

Origination of pigment stones is related to:
a. acute haemolysis
b. chronic haemolysis
c. hypercalcaemia
d. hyperlipoproteinaemia

The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are double reviewed.

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Due to practical focus of the journal we would like to ask you to write the paper comprehensively, with emphasis on practical use of provided information in out-patient practice of gastroenterologists and related specialisations.

Send contributions in the e-mail to the address: paulenova@amedi.sk
Period 4x per year
ISSN:1336–1473
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Gastroenterology for practice
Gastroenterology for practice
Reviewed, postgraduate scientific medical journal.
Period 4x per year
Predplatné