The prevalence of diabetes mellitus at higher age is higher than the prevalence of diabetes at younger age groups. There are a lot of patients who do not know about their afection. We have to distinguish between diabetic patients with diabetes appearance at younger age and longer duration of the disease and patients with diagnosis of diabetes in older age. The last group has better prognosis. The therapy of diabetes athigher age requires more caution concerning the choice and the dose of drugs as well as to consider possible drug interactions caused by polytherapy and polypragmasy.Diabetes athigher age has typical microangiopatic and especially macroangiopatic complications with the necessity to cure associate arterial hypertension and hyperlipidaemia to decrease the cardiovascular morbidity and mortality.