Juraj Hrnčiar, Mária Hrnčiarová, Gabriela Kaliská, Jarmila Okapcová
Prinzmetal´s angina pectoris occurs in 2 - 3 % of patients with coronagraph. 14 % of microvascular angina pectoris was found in 500 patients indicated for coronagraph. Incidence o fit was 4.1 times higher in periclimacteric, android obese and benign hirsute women. Microvascular and vasospastic angina pectoris with the presence of insulin resistance syndrome and insulin sensitivity indices did not differ from patients with significant coronary stenoses, if subjects of the same sex, age and BMI were compared. At the background of microvascular angina pectoris there was in 4.3 % hormonally active tumor present and a certain grade of coronary atherosclerosis together with dysfunction of impaired vascular endothelium and with over production of katecholamines as well as vasospastic endothelin-1 and deficit of production of vasodilated NO. The cause of microvascular and vasospastic angina pectoris or tako-tsubo cardiomyopathy might be various endocrine, seemingly subclinical tumors inducing electrolyte disorders(Conn´s syndrome, Cushing´s syndrome, primary hyperparathyreosis), mainly pheochromocytome co-producing together with katecholamines also endothelin -1 and serotonin which participate in triggering of coronary vasospasms.