Vladimír Bartoš, Jaroslav Ivan, Lívia Jančiová
Eosinophilic myocarditis (EM) is a rare form of myocardial inflammation histologically characterized by various intensive inflammatory infiltration of tissue with a predominance of eosinophilic leukocytes. In fact, it represents only a morphological diagnosis that may manifest in the setting of different clinico-pathological entities. EM occurs in some systemic disorders, parasitic infections, allergic reactions, and a special prognostically poor type is the acute necrotizing eosinophilic myocarditis. Hypersensitivity form of inflammation belongs to one of the most common type occuring as a response to various medicaments use. EM usually has only inapparent and nonspecific clinical symptoms that often overlap with another pathological conditions. Therefore, a diagnostic process is difficult in a routine practice. In most cases, diagnosis is revealed only incidentally in a necroptic material. Because the inflmammatory infiltrate is frequently focally localized in the myocardium, it often is not detected in biopsy and autopsy tissue examination. Therefore, it can be assumed that EM is really not a rarely occured, but rather a rarely diagnosed disorder.