Zbynek Schroner, Vladimír Uličiansky
Enhancement of incretin effect (glucagon-like peptid-1 analogues and inhibitors of dipeptidyl peptidase-4) is a completely new therapeutic approach in the treatment of diabetes mellitus type 2. Incretin-based therapy has positive effect also on such ethiopathogenetic mechanisms of development of diabetes mellitus type 2 (reduced incretin effect, increased secretion of glucagon) which were not affected by previous therapeutic modalities. Another possible new way in the treatment of diabetes mellitus type 2 is represented by sodium-glucose co-transporter-2 (SGLT2) inhibitors which are in late phases of clinical testing and their introduction to market is expected in near future. This class of drugs affects different ethiopathogenetic mechanism of development of diabetes mellitus type 2 - increased reabsorbtion of glucose in proximal renal tubule.