Sympatolytics, which intervene on central level in regulation centres of arterial pressure in brain stem and CNS, not only effectively lower blood pressure but they also reduce manifestations of sympatholytic excessive activity and improve insulin sensitivity. To the programme TEMPO we assigned 1 079 patients treated for arterial hypertension and metabolic syndrome with the aim to find out how they will change stress perception under the treatment by preparation Tenaxum® and if these changes are associated with blood pressure changes. The treatment by preparation Tenaxum® in the period of 3 months was associated not only with a significant decrease of systolic and diastolic pressure, heart frequency but also with a significant reduction of a point score questionnaire for excessive stress. It means that stress manifestations were alleviated together with the drop of these parameters. It is remarkable that between changes in the point score at the beginning and at the end of the programme and changes in the values of systolic pressure and heart frequency we detected a positive reaction.