Ján Murín
Nowadays, diabetes mellitus type 2 has become an epidemic of the modern world. Besides this, at present diabetics die and suffer mainly from cardiovascular complications and diseases. It is also the reason why in the case of searching for a new medicament for diabetics, it is expected from them to influence favourably cardiovascular risk factors and to protect the structure and function of cardiovascular system. Incretins also belong here. The paper focuses on extraglycaemic effects of these medicaments with the stress on cardiovascular benefits. Here belong: moderate decrease of blood pressure, support of production of NO in endothelium, vasodilation, improvement of heart function, protection against ischaemia in the myocardium, adjustment of myocardial “stunning”, renoprotection and antiinflammatory effects. It is assumed that clinical studies will also prove clinical cardiovascular benefits in those medicaments.