Monika Vaľková, Ivica Lazúrová, Darina Petrášová, Mária Frankovičová
Peripheral arterial occlusive disease is a serious disease of multifactorial genesis. In addition to traditional risk factors
in its pathogenesis apply to a variety of inflammatory markers whose meaning is not yet sufficiently understood.
The goal was to determine the relationship between biochemical markers of vascular inflammation and the morphological
indicators of PAD: ankle-brachial index (ABI) and inthima-media thickness of common femoral artery (IMT AFC).
Objective: The group consisted of 55 patients with PAD a 34 control subjects. We measured glycemia, insulinemia, lipid
profile, CRP, TNF-alfa, IL-6 and ABI, IMT AFC in both groups.
Results: Patients with PAD were slightly but significantly older and there were also different in the number of cigarettes
smoked per day (p = 0,0013). We observed significant increased levels of cholesterol, triglycerids, glycemia, CRP,
TNF-alfa and IL-6 and lower HDL cholesterol in group of PAD as compared with those without PAD. HDL cholesterol
directly correlated with ABI (0,0001) and indirectly with IMT AFC (0,0001). There was a positive association between
TNF-alfa and IMT AFC (0,0001).
Conclusion: From the traditional risk factors of low HDL cholesterol was the closest relation to the ABI and IMT. The main
finding in this study was a significant relationship between inflammatory markers and ABI and IMT AFC levels, in particular
CRP and TNF-alpha, which may contribute significantly to the pathogenesis of the disease.