František Nehaj, Michal Mokáň, František Kovář, Marián Mokáň Marianna Kubašková
Low molecular weight heparin (LMWH) is mainly used as a prevention and therapy of venous thromboembolism. They
are heparin salts of various molecular weight (< 8 000 Da) and are obtained by depolymerisation or fractionation from
heparin polymer. The effect of LMWH on a coagulation is monitored by activity of anti-Xa, which explains that high values
indicate high anticoagulation activity and low values low anticoagulation activity. Considering different molecular
weight, we distinguish at least eight types of LMWH with different chemical, biological and physical properties. We present
a case report of seventy years old female with paroxyzmal atrial fibrillation. Subcutaneous application of LMWH
led to iatrogenic haemorrhagic shock with urgent surgical intervention.