Marek Rác, Tomáš Koller, Andrej Klepanec, Ivan Vaňo, Marián Streško, Marián Bakoš, Peter Jarčuška, Ľubomír Skladaný
Introduction: Obesity and metabolic syndrome are known risk factors for the non-alcoholic fatty liver disease (NAFLD) origination.
NAFLD presents a liver manifestation of metabolic syndrome. NAFLD is a multifactorial disease and leads to progression
and development of hepatic and extrahepatic complications. Hepatocellular carcinoma (HCC) is the most common primary
hepatocellular carcinoma and actually the fifth most common carcinoma. HCC has the fastest growing incidence among solid
tumours and presents one of the most lethal carcinomas with high fatality. It originates mainly in the terrain of chronic inflammatory
liver disease, which led to cirrhosis. HCC originating in the non-cirrhotic liver has its aetiological specifics, out of them resulting
cytogenetic, histopathological and clinical differences.
The aim of the work: To identify and find out: 1) the share of NAFLD aetiology in the HCC cohort; 2) the proportion of NAFLD
HCC in the non-cirrhotic terrain; 3) differences between subgroups NAFLD HCC versus other aetiology; 4) differences between
non-cirrhotic HCC and HCC found in the cirrhosis terrain.
Methods and patients: Retrospective analysis of patients with HCC, a cohort of consecutively diagnosed patients with HCC from
the hepatological centre in Faculty Hospital Nitra, time interval 1/2012 – 8/2016. Inclusive criteria: HCC diagnosis. Exclusive criteria:
lack of data. Recorded variables: demographic data, aetiology of liver diseases, presence or absence of liver cirrhosis (USG,
CT, MRI, EGDS) or histology.
Results: We analysed 103 patients (n=103). Selected variables of the cohort: age = 68 (14 – 86), the share of women = 19 %; aetiology
of liver disease = ALD – 57 %, NAFLD – 42 %, Hep-B + Hep-C – 7 %, AIH – 6 %. 19 patients (20 %) from our cohort did
not have proved liver cirrhosis; 71 % of them had NAFLD aetiology of HCC; 53 % created women (vs 12 % in Ci-HCC cohort,
p = 0.0001). When comparing NAFLD-HCC (n = 40) with non-NAFLD-HCC (n = 55) we detected differences: age: 68.6 % vs 66.9 %
(p = 0.4); women: 27.5 % vs 16.4 % (p = 0.2); cirrhosis presence: 70 % vs 91 % (p = 0.008); patients from surveillance: 2.6 % vs
16.4 % (p = 0.035); survival median: 371 vs 352 days (p = 0.86). When comparing subgroups of cirrhotic HCC versus non-cirrhotic
HCC we detected: age: 69 vs 68 (p = 0.); share of women: 11.9 % vs 52.6 % (p = 0.0001); NAFLD: 35.9 % vs 70.6 % (p = 0.01).
Conclusion: A significant part of patients have HCC with non-cirrhotic terrain (20 %). Aetiologically it is dominantly NAFLD.
NAFLD presents a common HCC aetiology (42 %). NAFLD is a risk factor for HCC origination in non-cirrhotic terrain. We neither
proved a statistically significant difference in survival related to aetiology nor to the presence or absence of cirrhosis.