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Časopis Internal medicine – Článok The relationship of selected gene variants to manifestations of subclinical atherosclerosis in peripheral arteries in type 2 diabetics

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Téma: Original works

The relationship of selected gene variants to manifestations of subclinical atherosclerosis in peripheral arteries in type 2 diabetics

Zuzana Malachovská, Miriam Kozárová, Martin Javorský, Ivan Tkáč

Introduction: Endothelial dysfunction (ED) is characterized as functional, reversible damage to endothelial cells resulting
from oxidative stress and changes in the bioavailability of nitric oxide. ED is an intermediate stage in the development
of atherosclerosis.
Aim: The aim of the study was to find out in the Slovak population the frequency of alleles and genotypes of selected gene
polymorphisms associated with the manifestations of subclinical atherosclerosis in peripheral arteries in the risky population
of type 2 diabetics.
Methods: Genetic association study included 124 asymptomatic type 2 diabetics of average age of 62,9 ± 9,1 years.
Each of the patients went through a complex vascular protocol aimed at detecting of subclinical atherosclerosis in the
peripheral arteries, specifically pulse wave velocity (PWV) measurement, intima-media thickness (IMT) and flow-mediated
dilation (FMD). The DAB2IP rs7025486, PAX2 rs6584389 and Hp rs72294371 gene polymorphisms were tested.
Results: The DAB2IP rs7025486, PAX2 rs6584389 and Hp rs72294371 polymorphisms were significantly associated with
intima-media thickness (IMT average and IMT of the left side). In multivariate linear regression analysis with mean IMT
as a dependent variable, among the genetic factors, the C allele of polymorphism PAX2 rs6584389 was a significant IMT
thickness predictor (β = 0,0460; p = 0,029). From the other genetic factors, the strongest predictors were: asymmetric
dimethylarginine (ADMA) (β=0,200; p = 0,022), glycated hemoglobin (HbA1c) (β = 0,0237; p = 0,003), male gender
(β = 0,0952, p = 0,011) and age (β = 0,00953; p < 0,001).
Conclusion: Due to the independence from traditional risk factors of atherosclerosis, detected gene polymorphisms,
DAB2IP rs7025486, PAX2 rs6584389 and Hp rs72294371, may point to new mechanisms of atherogenesis with potential
direct implication for practice in terms of individualization of therapy in carriers of these polymorphisms.

Interná med. 2017; 17 (7-8): 317-321
CELÝ OBSAH ČLÁNKU JE DOSTUPNÝ IBA PRE PRIHLÁSENÝCH PREDPLATITEĽOV Prihlásiť sa

Ročník 2017  Témy časopisu Internal medicine 7 / 2017

Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

EDITOR-IN-CHIEF
Eva Stachová
e-mail: stachova@amedi.sk 

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1. An accurate paper title, names and surnames of all authors including titles, authors` workplace. The first author address including the phone number, fax and e-mail address.

2. Summary - concise content summary in the extent maximum 10 lines (only at overview papers, case studies and Appendices - General Medicine). Write in 1st or 3rd person singular or plural (unify according the type of an article).

3. Key words - in the extent of 3-6 (only for overview papers and Appendices - General Medicine). 4. English translation: paper title, summary, key words (only at overview papers, and Appendices - General Medicine)

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Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
5. Osborne BE. The electrocardiogram of the rat. In: Budden R, Detweiler DK, Zbinden G. The rat electrocardiogram in pharmacology and toxicology. Oxford: Pergamon Press 1981: 15-27.

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a. genetic predisposition
b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor


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Due to practical focus of the journal we would like to ask you to write the paper comprehensively, with emphasis on practical use of provided information in out-
patient internists and general practitioners.


Send contributions in the e-mail to the address: stachova@amedi.sk
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)