The article presents the historical review of peptic ulcer therapy. Diet used to be the basis of the therapy. In 1960 the evidence that no diet could speed up the peptic ulcer healing was confirmed. Medicamentous therapy has undertaken a checkered development. Antacides dominated several decades later supplemented by parasympaticolytics ( anticholinergics). The effort to increase protective potential of the endogastric mucosa brought carbonexolon, sucralfate, complex vismut salts (coloid vismut). The effect of these substances was partial and in carbonexolon limited by adcerse effects.Inhibition of gastric acid secretion by H2 receptors blockage was the important success in the therapy. Cimetidin was the first antagonist of H2 receptors followed by further preparations of this drug group ( ranitidin, famotidin, etc.). Then the discovery of the proton pump and its inhibitors followed. The first used inhibitor of the proton pump was omeprasol which is in use in the therapy of HP erradication until present time.