Anton Vavrečka, Ladislav Kužela, Marian Oltman, Tatiana Novotná
Peptic ulcer disease (PUD) is defined by peptic ulcers and erosions of stomach and duodenum that are Helicobacter pylori (HP) positive. Therapy of PUD consists of antisecretory and eradication drugs. These include the combination of proton pump inhibitors (PPI) and antimicrobial drugs (antibiotics or chemotherapeutics). The eradication success after a 7-day herapy is over 90 %. 90 % of duodenal ulcers and a slightly smaller percentage of gastric ulcers are healed after 2-3 weeks of therapy. The recurrence rate of acute ulcers and their complications is substantially diminished. The majority of the patients can be completely cured with the above-mentioned therapy.