Acute bleeding into the GI tract is an extremely severe complication in which together with present risk factors the mortality from bleeding is about 10 % in all cases. The basic diagnostic and therapeutic approach is acute oesophagogastroscopy. The procedure is effectible after cardiopulmonal stabilisation of the patient. Drugs used in patients with acute bleeding from the upper GI tract react mostly to gastric pH and stabilisation of mucosal coagulation (H2 blockers, proton pump blockers) and guide blood flow in the splanchnic bloodstream. Numerous studies have showed higher effectiveness in parenteral PPI administration than H2 blockers. Effectiveness of somatostanin and its analogue octreotid has not been showed. Proton pump blockers have been indicated to prevent bleeding into upper GI tract to start (e.g. postmedicamentous mucosal lesion), and also as a successive therapy after endoscopic treatment of the bleeding.